The Galacticos were stunned in last week's Champions League semi-final first-leg in Germany as Robert Lewandowski fired home four goals for the big-hitting Bundesliga outfit.
Madrid did manage to bounce back from that loss with a 2-1 victory over city rivals Atletico Madrid in the Primera Liga on Saturday, although the result had little bearing on the league title race, with Barcelona still 11 points clear with five games remaining.
Jose Mourinho's side do, however, take a precious away goal into the return leg this week, with Cristiano Ronaldo having temporarily equalised at the Signal Iduna Park.
Mourinho may have to do without the Portuguese superstar this week, though, as he continues to struggle with a thigh strain he sustained in that game, an injury which ruled him out of the La Liga victory over Atletico.
However, Angel Di Maria is available after having missed the first-leg due the birth of his daughter the day before, which means Luka Modric is expected to drop to the bench.
Michael Essien has, meanwhile, returned to fitness and offers Mourinho another option, although the boss is expected to stick with Sergio Ramos at right-back, with Pepe and Raphael Varane lining up in the centre of defence.
Dortmund, meanwhile, are unlikely to field anything other than a full-strength squad, although Lukasz Piszczek is doubtful with a groin strain while Ilkay Gundogan (neck) and Mario Goetze (hip) are also facing late fitness tests.
The winner of Tuesday's clash will face either Bayern Munich or Barcelona in the European Cup showpiece next month, with the Bavarians heavy favourites to progress after bashing the Catalan club 4-0 at the Allianz Arena last week.
Many favour Dortmund to qualify ahead of Real madrid which I am not a subscriber to that idea.
I see Real Marid coming back to perform what seen to be the impossible. People tend to forget that all madrid need is to score three unreplied goals (I wonder when goal scoring became a problem for Real madrid).
Real Madrid have scored a total of 85goals this season in the spanish La liga only Barcelona have scored more with 101 and have conceeded just 31goals.
Rea Madrid are yet to loose at the Bernabeau this season in the champions league a trend which i see to continue tonight. By the way Cristiano Ronaldo will be making history if he scores tonight.
Though the road to the final may look too narrow and rocky for Mourihno and his men, but I still see them sneaking their way to Wembly if only Ronaldo, Benzema, Mesut Ozil and Angel Di Maria put on their right pair of boots.
I maybe the only one in the world saying this but I strongly believe Madrid still have a chance.
Do you think otherwise? then let us know by dropping your comment below.